Table 2 Concentrations (pg/mg) of endogenous brain oxytocin (OT).
From: Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
Dose-Route d5OT | 80 IU IN | 40 IU IN | 80 IU IV | |||
|---|---|---|---|---|---|---|
Monkey ID# (Sex) | ID #2 (M) | ID #4 (M) | ID #1 (F) | ID #5 (F) | ID #3 (F) | ID #6 (F) |
Brain Region | BRAIN OT concentration (pg/mg) | |||||
Cerebellum | ND | 0.06 | 2.16 | 0.12 | ND | + |
Brainstem | 5.11 | 3.55 | 7.27 | 9.34 | 10.93 | 3.58 |
Striatum | 1.58 | 17.81 | 0.63 | 1.20 | 14.45 | 15.82 |
Amygdala | 5.82 | 23.97 | NM | 39.11 | 4.63 | 7.26 |
Thalamus | 1.02 | 3.09 | 4.39 | 7.31 | 3.85 | 28.34 |
Visual Cortex | ND | ND | ND | ND | ND | ND |
Insular Cortex | ND | 0.06 | Â | 0.30 | 0.16 | ND |
dPFC | ND | 0.20 | ND | 0.16 | 0.27 | ND |
mPFC | ND | 0.45 | 0.86 | 0.88 | ND | ND |
OFC | 0.40 | 1.59 | 0.22 | 0.96 | 0.44 | ND |
Hypothalamus | 943.27 | 2186.74 | 1491.96 | |||
Hippocampus | 2.83 | 0.99 | 0.99 | |||
