Fig. 1: Single-cell proteomic and metabolic analysis of early drug response in M397 cells. | Nature Communications

Fig. 1: Single-cell proteomic and metabolic analysis of early drug response in M397 cells.

From: Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line

Fig. 1

a The single-cell integrated proteomic and metabolic analysis experiments design. Cells from different time points during BRAFi treatment are collected and individually analyzed using the microfluidic-based single-cell barcode (SCBC) technology. Each cell was characterized for the levels of six different categories of markers. b Heatmap representation of integrated proteomic and metabolic analysis dataset. Each row represents an individual cell and each column (except the last column) represents an individual analyte, with the color in the heatmap representing the measured level of the analyte. The last column represents the number of days after starting BRAFi treatment. On the X-axis, markers are colored corresponding to which of the six functional categories they belong to. c Violin plot representation of the distribution of certain representative markers across four time points. Y-axis represents the natural log of the measured marker level. Each plot is bordered by the color of the functional category of the measured marker.

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