Table 1 Biometric and echocardiographic parameters of DM1 mice.

Parameter	WT-Con (n = 6)^a	WT-STZ (n = 7)^a	MD2KO-Con (n = 6)^a	MD2KO-STZ (n = 7)^a
IVSd (mm)	0.84 ± 0.03	0.74 ± 0.02^*	0.77 ± 0.01	0.77 ± 0.01^#
IVSs (mm)	1.10 ± 0.08	0.95 ± 0.02^*	0.96 ± 0.02	0.96 ± 0.01^#
LVd (cm)	0.26 ± 0.01	0.24 ± 0.02	0.25 ± 0.01	0.25 ± 0.01
LVs (cm)	0.14 ± 0.003	0.13 ± 0.002	0.14 ± 0.007	0.14 ± 0.005
FWd (mm)	0.88 ± 0.037	0.73 ± 0.009^***	0.77 ± 0.009	0.76 ± 0.012^#
FWs (mm)	1.123 ± 0.07	0.96 ± 0.02^**	0.99 ± 0.01	0.98 ± 0.02^#
PWd (mm)	0.84 ± 0.03	0.75 ± 0.02^*	0.76 ± 0.02	0.78 ± 0.01^#
PWs (mm)	1.06 ± 0.04	0.95 ± 0.02	0.98 ± 0.02	0.98 ± 0.02
EF%	82.12 ± 2.0	70.57 ± 2.3^**	80.78 ± 1.7	80.37 ± 1.3^##
FS%	44.48 ± 1.9	36.14 ± 2.0^**	43.50 ± 1.7	42.84 ± 1.2^##
E (m/s)	0.452 ± 0.07	0.458 ± 0.06	0.612 ± 0.04	0.583 ± 0.05
A (m/s)	0.531 ± 0.02	0.322 ± 0.06	0.632 ± 0.06	0.628 ± 0.08
E/A	0.842 ± 0.13	1.615 ± 0.20^**	1.002 ± 0.09	1.033 ± 0.15^#
IVRT(ms)	12.1 ± 1.38	21.14 ± 1.86^*	13.8 ± 2.12	16.3 ± 2.22^#
HW (mg)	125.1 ± 3.28	117.8 ± 1.42	131.0 ± 4.55	116.0 ± 2.92
BW (g)	29.68 ± 0.95	25.30 ± 0.38	32.17 ± 1.70	27.07 ± 0.48
HW/BW (mg/g)	4.218 ± 0.065	4.660 ± 0.031^**	4.093 ± 0.082	4.281 ± 0.075^#
CK-MB	22.15 ± 4.174	59.47 ± 4.200^***	28.88 ± 1.835	37.25 ± 2.820^##

IVSd interventricular septal dimension in diastole, IVSs interventricular septal dimension in systole, LVd left ventricle in diastole, LVs left ventricle in systole, FWd left ventricular free wall in diastole, FWs left ventricular free wall in systole, PWd posterior wall thickness in diastole, PWs posterior wall dimension in systole, EF ejection fraction, FS fractional shortening, E peak mitral E velocity, A peak mitral A velocity, IVRT isovolumic relaxation time, HW heart weight, BW body weight, CK-MB creatine kinase-muscle/brain.
^aValues shown as mean ± SEM.
*p < 0.05, **p < 0.01, ***p < 0.001 compared with WT-Con; ^#p < 0.05, ^##p < 0.01 compared with WT-STZ. P-values by one-way ANOVA followed by Tukey’s post hoc test are indicated.

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