Fig. 2: Non-invasive MRI of BCSFB function: application to the ageing brain.
From: Non-Invasive MRI of Blood–Cerebrospinal Fluid Barrier Function
a The normalised cortical ASL signal as a function of TI for the adult (black) and aged (grey) cohort. Error bars represent SEM across the group; inset: the estimated cortical blood flow for each individual subject. n = 12/11 biological independent animals examined over 12/11 independent experiments for each group, respectively. **p = 0.0021 from a one-tailed t-test. b The normalised lateral ventricle BCSFB-ASL signal as a function of TI for the aged (grey) and adult (black) cohort; error bars represent SEM across the group. Inset: the estimated rate of BCSFB-medicated blood water delivery to the lateral ventricles for each individual subject. n = 12 and 11 biological independent animals examined over 12 and 11 independent experiments for the adult and aged group, respectively. ***p = 0.00006 from a one-tailed t-test.
