Fig. 9: Model of ET-1 signaling in the postnatal SVZ.
From: Endothelin-1 signaling maintains glial progenitor proliferation in the postnatal subventricular zone
a In the developing postnatal SVZ, RGCs secrete ET-1, which binds to Ednrb receptors on RGCs in an autocrine manner to activate Notch signaling. This leads to upregulation of stem cell genes and downregulation of proneural factors, resulting in RGC maintenance and proliferation. ET-1 also binds to Ednrb receptors on OPCs within the SVZ to upregulate the transcription factor Gsx1 and downregulate OL maturation factors S100b and Ust, thereby promoting OPC proliferation and blocking maturation. b Following demyelination of the SCWM, Type B cells in the adult mouse SVZ upregulate ET-1. This induces upregulation of Notch signaling components Jag1 and Hes5 in Type B cells, leading to increased proliferation. ET-1 also induces upregulation of Gsx1 and downregulation of S100b in SVZ OPCs, increasing their proliferation as well.
