Fig. 3: Dysregulation of two clustered miRNAs in SCNT placentas.
From: Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
a, b Scatterplot analysis of all miRNAs based on their expression levels in cumulus- a and Sertoli- b derived SCNT placentas compared with those detected in IVF placentas. Red and blue dots represent miRNAs from the Sfmbt2 and Mirg clusters, respectively. Dotted lines represent >1.3-fold changes. c Expression levels of Sfmbt2 and Mirg miRNAs. The Sfmbt2 miRNAs were highly expressed in SCNT placentas, regardless of the donor cell type. The Mirg miRNAs had lower expression levels in SCNT placentas and they exhibited donor cell type dependency. Also see Supplementary Figs. 2 and 3. N represents the number of biological replicates. The error bars represent the SEM. The Source data of Fig. 2c are provided as a Source data file.
