Fig. 6: Transcriptome analysis of IVF and SCNT placentas from wild type and miRNA KO.
From: Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
a Principal component analysis of IVF, SCNT wild type, miRNA KO, and miRNA/Gab1 KO placentas at E11.5 and E19.5 (term). The numbers within brackets indicate the number of biological replicates. b Numbers of DEGs in SCNT (wild type and two types of KO) placentas vs IVF placentas. c Box plots showing the expression levels of Sfmbt2 pri-miRNAs (Mir467b, Mir297b, and Mir669a-3) and placenta-specific imprinted genes (Sfmbt2, Gab1, and Slc38a4) in IVF and SCNT placentas. Upper, lower, and center lines indicate minimum, maximum, and mean values. The mean expression level in all samples is indicated as 0.0. +, wild type; Δm, maternal KO. Also see Supplementary Figs. 4 and 5, and Supplementary Data 2–6. Source data are provided as a Source data file.
