Fig. 1: Chromothriptic patterns and prevalence in 316 whole-genome sequences.

a Chromothripsis scoring: criteria to determine the confidence of the scoring and to define canonical versus non-canonical chromothripsis. b Representative example of canonical chromothripsis. c Representative example of non-canonical chromothripsis. In this case, the centromere is included in the chromothriptic region. d Representative example of chromothriptic chromosome for which the telomere region is involved. e Chromothripsis prevalence shown as percentage of cases (n = 316, whole-genome sequencing) including cases with high confidence, intermediate confidence and low confidence chromothripsis. For tumours with high confidence chromothripsis, we distinguish between canonical and non-canonical chromothriptic patterns. f Chromothripsis cases with multiple versus single chromosomes affected; with or without telomere involvement (illustrated in d), as well as with or without centromere involvement (illustrated in c) from all 316 cases. High confidence, intermediate confidence and low confidence chromothriptic cases are shown. g Venn diagram showing the overlapping fractions of high confidence chromothriptic cases with multiple chromosomes affected, with or without involvement of telomeres and/or centromeres. Analyses based on whole-exome sequences and examples showing the counting of switches between copy-number states are shown in Supplementary Figs. 1–2. On the copy-number plots, blue lines indicate inversions, green lines indicate break ends, brown lines indicate translocations and orange lines indicate copy-number variation.