Fig. 4: Gene fusions generated by chromothriptic events.
From: The landscape of chromothripsis across adult cancer types
a Tumours with chromothripsis have more gene fusions per structural variant. Regression analysis for the number of fusions depending on the number of structural variants in tumours with or without chromothripsis (see Supplementary data 4 for all parameters of the regression analyses). b Chromothripsis generates clinically relevant gene fusions, as illustrated with the MYB – NFIB fusion, which drives tumour development in adenoid cystic carcinoma. Blue lines indicate inversions, green lines indicate break ends, brown lines indicate translocations and orange lines indicate copy-number variation.
