Fig. 5: Metabolic and endocrine parameters before chemotherapy compared between compliant and non-compliant patients halfway therapy of the FMD group and the regular group. | Nature Communications

Fig. 5: Metabolic and endocrine parameters before chemotherapy compared between compliant and non-compliant patients halfway therapy of the FMD group and the regular group.

From: Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial

Fig. 5

Values are measured on day −1 or day 0 before cycle 1 and halfway therapy. *P-value <0.05, **P-value <0.001 (2-sided). Error bars indicate the standard error of the mean (if data was normally distributed) or the 25% and 75% percentiles of the median (if data was non-normally distributed). Independent t-tests and Mann-Whitney tests were used. Reference values: glucose 3.1–6.4 mmol/L; insulin 0–20 mU/L; IGF-1 5.4–24.3 nmol/L. Abbreviations: FMD: fasting mimicking diet, IGF-1: Insulin-like growth factor 1. Source data are provided as a Source Data file.

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