Fig. 4: Binding of MXN and SN38 to ABCG2.
From: ABCG2 transports anticancer drugs via a closed-to-open switch
a View of ABCG2 TM helices in the inward conformation bound to MXN. TM2 is colored magenta, and TM5 is colored green. b View from the extracellular space showing that MXN binds between Phe439 from opposing monomers. c Zoomed-in view of the MXN binding site with MXN shown in blue. TM2 and associated density from each monomer is shown as magenta sticks. d View of ABCG2 TM helices in the inward conformation bound to SN38. TM2 is colored magenta, and TM5 is colored green. e View from the extracellular space showing that SN38 binds between Phe439 from opposing monomers. f Zoomed-in view of the SN38 binding site with SN38 shown as yellow sticks. TM2 is shown as magenta sticks.
