Fig. 2: Uncontrolled YAP1 in NEX-Cre-expressing cells is sufficient for tumour formation at the expense of hippocampal differentiation. | Nature Communications

Fig. 2: Uncontrolled YAP1 in NEX-Cre-expressing cells is sufficient for tumour formation at the expense of hippocampal differentiation.

From: YAP1/TAZ drives ependymoma-like tumour formation in mice

Fig. 2: Uncontrolled YAP1 in NEX-Cre-expressing cells is sufficient for tumour formation at the expense of hippocampal differentiation.

a Immunofluorescence staining of YAP1 in coronal vibratome sections of P0 animals. Neurons in nlsYAP5SA mouse cortex show strong nuclear staining of YAP1. Hippocampus formation is altered in nlsYAP5SA (arrowheads). Scale bars = 1 mm. b Arrowheads pointing at tumours visible in coronal vibratome sections of a P0 nlsYAP5SA animal. Scale bars = 1 mm. c Immunofluorescence staining in coronal sections of tumours in a nlsYAP5SA mice. Tumours are outlined with yellow-dashed line. Nestin, Ki67 and MUC1 demonstrate highly intense staining in the tumours while NeuN is absent. Scale bars = 100 µm.

Back to article page