Fig. 4: YAP1 and TAZ are necessary for tumour development in LATS1/2 cKO mice.
From: YAP1/TAZ drives ependymoma-like tumour formation in mice
a Breeding scheme to generate a rescue model. Available animals (Lats1f/f Lats2f/f, YAPf/f TAZf/+ and NEXCre/Cre) were crossed to generate mice with shown genotypes. b Measurements of size of tumours found in LATS1/2 cKO (n = 16 tumours), Mutant YAPf/+ (n = 15 tumours) and Mutant YAPf/f (n = 11 tumours) from n = 3 mice for each genotype. Colour shade indicates tumours from the same animal. LATS1/2 cKO tumour volumes compared with those measured in Mutant YAPf/f animals show a significant difference with padj = 0.0006 (two-sided Dunn’s multiple comparison test). Error bars = SEM. c Coronal vibratome sections of P20 brains stained for DAPI. No tumour formation identified in Rescue mice. Tumours (arrowheads) can be found in LATS1/2 cKO, Mutant YAPf/f and Mutant YAPf/+ animals. Scale bars = 1 mm.
