Fig. 4: Hypomyelination of GABAergic parvalbumin interneurons in APO-SUS versus APO-UNSUS mPFC.

a Representative images and quantification of the proportion of myelinated axons (MBP+) that is GABAergic (% GABA+ of total MBP+ axons) or non-GABAergic (% GABA− of total MBP+ axons) in IL layer V of APO-SUS (n = 3) versus APO-UNSUS (n = 3) rats. Scale bars 5 µm and 2 µm in insets; *p = 0.021 in two-tailed independent samples t-test. b Representative images and quantification of the length of the nodes of Ranvier of GABAergic myelinated axons in APO-SUS (n = 3) and APO-UNSUS rats (n = 3). Scale bars 5 µm. c Representative images and quantification of the proportion of myelinated axons (MBP+) that are parvalbumin (PV) interneurons (% PV+ of total MBP+ axons). Scale bars 5 µm and 2 µm in insets; *p = 0.013 in two-tailed independent samples t-test. d Representative images and quantification of the number of PV interneurons/mm² in APO-SUS (n = 7) and APO-UNSUS (n = 5) mPFC. Scale bars 200 µm. Source data are provided as a Source data file.