Fig. 1: Palladium-catalyzed tandem Heck/carbonylation reactions of alkenes. | Nature Communications

Fig. 1: Palladium-catalyzed tandem Heck/carbonylation reactions of alkenes.

From: Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes

Fig. 1: Palladium-catalyzed tandem Heck/carbonylation reactions of alkenes.

a Pd-catalyzed tandem Heck/carbonylation as key step to the total synthesis of (+)-Perseanol. b Palladium-catalyzed asymmetric tandem Heck/carbonylation of internal alkenes towards bicyclo[3.2.1]octanes (this work). c Hypothesis of mechanism for the tandem Heck/carbonylation reaction and foreseeable side reactions.

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