Fig. 3: Substrate scope of phenols. | Nature Communications

Fig. 3: Substrate scope of phenols.

From: Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes

Fig. 3: Substrate scope of phenols.

Reaction conditions: 1a (0.1 mmol), 4 (0.25 mmol), Pd2dba3•CHCl3 (5 mol%), L1 (20 mol%), KHCO3 (0.2 mmol) in toluene (1 mL), 100 °C, 36 h, under CO (1 atm). Yields of isolated products are given. The dr values were determined by 1H NMR analysis. The ee values were determined by HPLC analysis on a chiral stationary phase.

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