Fig. 3: Significantly mutated UM genes.
From: Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours
Samples are arranged in the same order as Fig. 2 by their category (1–4). a Alterations (substitutions, indels, SVs and CNAs) in significantly mutated genes and known UM driver genes. Nonsense mutations and frame-shift indels are labelled LOF. Loss-of-function breakpoints due to structural variants are labelled SV. b Copy number status of the commonly aberrant chromosomes 1, 3, 6 and 8, in UM. c Positions of mutations in encoded protein of significantly mutated genes, CENPE, TP53 and RPL5. Mutations are coloured black (LOF) and green (missense). Proteins domains are depicted wider and structurally important regions are coloured dark grey (disorder), light green (coiled-coil) and light blue (low complexity).
