Fig. 5: The effect of oxygen tension on the risk of acquiring oncogenic mutations in in vitro-cultured PSCs.
From: The mutational impact of culturing human pluripotent and adult stem cells
a The number of oncogenic mutations as a function of the number of in vitro-produced cells for pluripotent stem cells cultured under 20% and 3% oxygen. b Top panels: genomic distribution of the observed versus the expected amount of mutations per genome per doubling. Bottom panels: log2 of the ratio between the total number of observed mutations versus the total number of the expected amount of mutations. Asterisks denote statistically significant differences between observed and expected (binomial test). CDS coding sequence.
