Fig. 5: In vivo time-resolved imaging with Ag2S superdots.
From: Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging
a NIR-II fluorescence images obtained at different times after intravenous injection of Ag2S superdots dispersed in PBS (100 µL, 0.15 mg mL−1). b Time evolution of the fluorescence intensity at the liver, spleen, heart, and femoral artery after intravenous injection of Ag2S superdots. c NIR-II ex vivo fluorescence and optical images of the liver, spleen, heart, and lungs obtained from a mouse euthanized 100 min after intravenous injection of Ag2S superdots. Time evolution of daily food intake (d), weight (e), and body temperature (f) of four CD1 mice after intravenous injection of 300 μL of a dispersion of Ag2S superdots in PBS (0.5 mg mL−1, total dose of 150 μg). The results obtained from a control group intravenously injected with 300 μL of PBS are included for comparison. Serum concentration (g) of hepatic enzymes (g, h and i) for mice intravenously injected with Ag2S superdots and control mice as obtained 1 and 28 days after injection. Serum concentration of creatinine (j) and bilirubin (k) corresponding to mice subjected to an intravenous injection of Ag2S superdots and control mice as obtained 1 and 28 days after injection. (n = 3 for each group). The error bars correspond to the standard error of the mean (±SEM).
