Fig. 3: SPINT1 is reduced in an independent high-risk cohort.
Plasma SPINT1 levels were assessed in samples from women who presented at the Manchester Antenatal Vascular Service (MAViS). SPINT1 is reduced in the SGA cohort (a, b, p = 3.31 × 10−4), with a step-wise reduction when SGA cases were split into 5–10th and <5th centile (c, 5–10th p = 2.83 × 10−2 vs control, <5th p = 1.10 × 10−3 vs control). We also confirm that circulating SPINT1 correlates across all birthweight centiles (d). Uterine artery pulsatility index was assessed at the time of blood sampling, as well as at 22–24 weeks, and for both of these measures we demonstrate a significant correlation with circulating SPINT1 (e, f). We also confirm a significant correlation between circulating SPINT1 and estimated placental surface area at 22–24 weeks. For all panels, each individual symbol represents one patient. a, b: n = 208, control, n = 83 SGA. c: n = 208 control, n = 40 5–10th, n = 43 < 5th. e: n = 221, f: n = 244, g: n = 223. *p < 0.05, **p < 0.01 using two-tailed Mann–Whitney U tests. AUC—area under the ROC curve, with 95% confidence intervals given in brackets. Data depicted for a and c are mean ± s.e.m. Source data included as a Source Data file.
