Table 1 Diagnostic performance of circulating SPINT1 concentrations at 35+0–37+0 weeks’ gestation to identify fetuses born at varying low birthweight cut-offs.

From: Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

 

Birthweight < 3rd centile

Birthweight < 5th centile

Birthweight < 10th centile

Birthweight < 20th centile

Birthweight < 5th centile and nursery admission

Positive predictive value

10.2% (5.2–17.5)

16.1% (9.8–24.2)

22.6% (15.3–31.3)

37.9% (29.3–47.1)

4.8% (1.6–10.8)

Negative predictive value

98.3% (97.2–99.1)

96.5% (95.1–97.6)

90.9% (88.9–92.8)

78.4% (75.5– 81.1)

99.7% (99.0–99.9)

Risk ratio (95% CI)

6.04 (2.85–12.82)

4.59 (2.66–7.93)

2.50 (1.68–3.71)

1.75 (1.35–2.27)

14.2 (3.44–58.47)

Sensitivity

42.3% (23.4–63.1)

36.7% (23.4–51.7)

24.5% (16.7–33.8)

19.9% (15.0–25.6)

62.5% (24.5–91.5)

Specificity

90.0% (88.0–91.8)

90.1% (88.0–91.9)

90.0% (87.9– 91.9)

89.9% (87.5–91.9)

89.9% (87.9–91.7)

  1. This data was derived from Cohort 2, our validation cohort and calculated from the 998 participants where there was a SPINT1 readout from the assay (a further four samples did not detect SPINT1 and were excluded).
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