Table 2 Four-tier risk model for delivery of neonates with different low birthweight cut-offs.

From: Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

TIER

SPINT1 MoM cut-off

% (no) within tier

Birthweight < 3rd centile

Birthweight < 5th centile

Birthweight < 10th centile

Birthweight < 20th centile

Birthweight < 5th centile and nursery admission

1: High risk

<0.63

7.1% (71)

14.1%

19.7%

28.2%

46.5%

7.0%

2: Normal risk

0.63–1.1

57.0% (569)

2.3%

4.4%

11.8%

27.4%

0.4%

3: Lower risk

1.1–1.6

26.8% (268)

1.1%

3.0%

6.3%

14.9%

0.4%

4: Lowest risk

>1.6

9.1% (91)

0.0%

1.1%

1.1%

6.6%

0.0%

  1. The data were derived from cohort 2 (validation cohort). Risk model developed by selecting different thresholds of circulating levels SPINT1 MoM concentrations measured among pregnant women at 35+0–37+0 weeks’ gestation.