Fig. 3: PNS macrophages constitutively express transcripts associated with activated microglia. | Nature Communications

Fig. 3: PNS macrophages constitutively express transcripts associated with activated microglia.

From: Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

Fig. 3: PNS macrophages constitutively express transcripts associated with activated microglia.

a Expression pattern of DEGs defined as PNS-enriched (red) or CNS-enriched (blue). CNS microglia includes brain and spinal cord and PNS macrophages include DRG, vagal, fascial, and sciatic nerves. b Circos plot showing the number of connections (gene connectivity) between GSEA-scored genes from microglia in 6 neurodegenerative and aging-associated conditions as defined in Krasemann et al.6 and neural macrophage-enriched genes from either PNS macrophages (red) or CNS microglia (blue). c PNS-enriched genes from connectivity groups 6–4 expressed as Log2 fold change (PNS macrophages/CNS microglia). d Expression plot comparing PNS macrophage-enriched genes (expressed as PNS macrophage/CNS microglia Log2FC) and Sall1−/− microglia-enriched genes (expressed as Sall1−/−/wild-type microglia Log2FC) from Buttgereit et al.28; r, correlation coefficient; p, p-value for linear regression analysis. e Representative immunohistochemistry in sciatic nerves of CX3CR1GFP/+ mice showing DAPI (blue), GFP (green), MHCII (white), and Clec7a (red). Scale bar, 50 μm. Source data are available as a Source Data file.

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