Table 1 Reaction optimization and control experiments.
From: Arene dearomatization through a catalytic N-centered radical cascade reaction
| |||
|---|---|---|---|
Entry | Photocatalyst | Solvent | Yield (%) |
1 | A | PhCF3 (0.2 M) | 48 |
2 | B | PhCF3 (0.2 M) | 32 |
3 | C | PhCF3 (0.2 M) | 7 |
4 | A | PhCF3 (0.05 M) | 67 |
5 | A | DMF (0.05 M) | 50 |
6 | A | CH2Cl2 (0.05 M) | 47 |
7 | A | 1,2-DCE (0.05 M) | 65 |
8 | A | t-BuOH (0.05 M) | 73 |
9 | A | PhCF3/t-BuOH (0.05 M) | 83 (75)a |
Variation from best conditions (Entry 9) | ||
|---|---|---|
10 | No blue LEDs | 0 |
11 | No photocatalyst | 0 |
12 | No NBu4OP(O)(OBu)2 | 0 |
