Fig. 8: Synthesis of antitumor agent Z and its difluoromethyl analog Z′.

Tf2O trifluoromethanesulfonic anhydride, DPPP bis(diphenylphosphino)propane, TFA trifluoroacetic acid, DIBAL-H diisobutylaluminum hydride.

Tf2O trifluoromethanesulfonic anhydride, DPPP bis(diphenylphosphino)propane, TFA trifluoroacetic acid, DIBAL-H diisobutylaluminum hydride.