Fig. 1: Gestational ethanol exposure (GEE) paradigm.
From: Gestational alcohol exposure disrupts cognitive function and striatal circuits in adult offspring
a Schematic diagram of the GEE paradigm. Mice were exposed to ethanol or air (CE) for 16 hours/day for 4 days/week from embryonic day (E)0.5 to postnatal day (P)10. The ethanol vapor concentration averaged 200 mg/dl from E0.5-E21. After birth the ethanol concentration was lowered to average 100 mg/dl. At 2–3 months, mice were either used for ex vivo electrophysiology or instrumental training (continuous reinforcement schedules (CRF), training under random interval (RI) and random ratio (RR) schedules, and outcome devaluation (DV) tests). b GEE elicited similar blood ethanol concentrations (BEC) in dams (from E0.5-E21.5) and pups (from P0-P10). However, GEE did not alter (c) litter size or (d) body weight of offspring at birth. Black bars = CE mice; red bars = GEE mice. Error bars equal ± SEM.
