Fig. 4: GEE increases MSN excitability and decreases GABAergic transmission onto DLS MSNs.
From: Gestational alcohol exposure disrupts cognitive function and striatal circuits in adult offspring
a GAD65-GFP slice with the DLS demarcated. b Response of MSNs to hyperpolarizing (bottom black), just suprathreshold (middle red), and strongly depolarizing (top black) currents from CE (top), injected current = −400, +300, and +600 pA, respectively, and GEE (bottom) current = −400, +220 and +600 pA, respectively. c Current-AP frequency relationship shows an increase in the max frequency of AP in GEE compared to CE. d Representative mIPSCs recorded from CE and GEE MSNs. Graphs showing that mIPSC e frequency, f amplitude, and g area are decreased in GEE compared to CE. h Representative paired-pulse traces from CEE and GEE DLS-MSNs. i Paired-pulse ratio of DLS-MSNs recorded from CE and GEE mice with interstimulus interval of 50 ms. Error bars equal ± SEM, *t-test = p < 0.05.
