Fig. 5: GEE decreases the efficacy of the parvalbumin-expressing interneuron to MSN synapse in the DLS.

a Schematic diagram of the synaptic connectivity of PVs and MSNs (Left), and endocannabinoid siganling at the PV-MSN GABAergic synapse. b, c Example of a section obtained from a parvalbumin (Pvalb)-cre transgenic mouse injected into the dorsal striatum with a Cre-sensitive viral vector (AAV2-DIO-ChR2-mCherry) following immunohistochemistry using an antibody raised against against pvalb and visualization of mCherry. d–f Increased magnification of boxed regions in b and c shows that a majority of neurons that express mCherry also express pvalb. g Responses of MSNs recorded within DLS slices obtained from CE and GEE mice to two 5-ms pulses of 488 nm wavelength with an interstimulus interval of 50 ms. h Paired-pulse ratio of DLS-MSNs recorded from CE and GEE mice. Error bars equal ± SEM, *t-test = p < 0.05.