Fig. 5: Electrostatic interactions in α-syn fibril polymorphs. | Nature Communications

Fig. 5: Electrostatic interactions in α-syn fibril polymorphs.

From: Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

Fig. 5: Electrostatic interactions in α-syn fibril polymorphs.The alternative text for this image may have been generated using AI.

Primary sequence of WT α-syn fibril core (FC) is shown on top. K residues are colored in blue; H is light blue; E/D is red. Interacting charged residues in the structures of different α-syn polymorphic fibrils are connected with solid lines. One layer of different polymorphic structures of α-syn fibrils are shown below. The dimeric α-syn molecules are colored in different levels of gray. Electrostatic interactions are highlighted with K colored in blue, H in light blue and E in red. PDB IDs of the structures are provided in parentheses.

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