Fig. 2: CeA ChR2 pairing controls pursuit of sucrose vs. cocaine.
From: The central amygdala recruits mesocorticolimbic circuitry for pursuit of reward or pain
a Sucrose–cocaine choice paradigm and timeline within an individual test session; nm, nanometers; s, seconds; min, minutes. b Earned rewards (via nosepokes on an FR1 schedule) during 2 h (h) sucrose vs. cocaine choice sessions. ChR2 rats, N = 11; eYFP rats, N = 5; two-way within and between subjects ANOVA, main effect of virus: F1,10 = 4.6, p = 0.046; ChR2 laser vs. nonlaser responses, two-sided paired t-test, t9 = 7.5, p = 0.000, 95% CI: 4.8, 9.2, d = 4.39. Individuals with laser-paired sucrose in yellow circles and cocaine in purple squares. c Percent preference for laser-paired reward on day 4 (ChR2 rats: N = 11; eYFP rats: N = 5; two-sided unpaired t-test, t10 = 3.4, p = 0.006, 95% CI: 13, 60, d = 1.81). d Number of earned rewards for sucrose reward versus cocaine reward on last choice session, separated by reward type. CeA ChR2 laser + sucrose: N = 5 rats, sucrose vs. cocaine alone: two-sided paired t-test, t3 = 4.72, p = 0.04, 95% CI: 1, 15, Cohen’s d = 5.11; CeA ChR2 laser + cocaine: N = 6 rats, sucrose alone vs. cocaine: two-sided paired t-test, t5 = 7.7, p = 0.000, 95% CI: 5.3, 9.2, d = 4.6). Control eYFP laser  +  sucrose: N = 2 rats, eYFP laser + cocaine: N = 3 rats; two-way repeated measures ANOVA, main effect of laser: F1,3 = 1.35, p = 0.33; h, hour. All data represent means and SEM. *p < 0.05, **p < 0.01, ***p < 0.001.
