Fig. 7: CeA ChR2 stimulation is unreliable as reinforcer alone.
From: The central amygdala recruits mesocorticolimbic circuitry for pursuit of reward or pain
a Laser self-administration task, in which touching a “laser spout” earned a laser stimulation (1-s or 8-s duration) and touching a separate “Inactive spout” earned nothing. b Placement map shows horizontal view of CeA optic fiber placements (size determined be average Fos plume from Fig. 1) with color of each placement indicating an individual rat’s # of laser self-stimulations per 30-min test. c Total laser self-stimulations earned by rats from sucrose/cocaine experiments (ChR2 rats, N = 10 vs. eYFP rats, N = 5, 1 s laser duration, left: two-way ANOVA, virus × laser interaction: F1,15 = 1.71, p = 0.21; 8 s laser duration, right: two-way ANOVA, virus × laser interaction: F1,15 = 2.06, p = 0.18). d Total laser self-stimulations earned by rats from shock-rod experiments (ChR2 rats, N = 18, eYFP rats, N = 6, 1 s laser duration, left: two-way ANOVA, virus × laser interaction: F1,18 = 0.07, p = 0.8; 8 s laser duration, right: two-way ANOVA, virus × laser interaction: F1,18 = 1.93, p = 0.18). All data represent means and SEM; n.s., not significant.
