Fig. 3: Targeting efficiency and therapeutic efficacy of MM-AT-NPs and AT-NPs/MAs.
a Schematic illustration of preparation of AT-NPs/MAs. b, c Ex vivo fluorescence bio-imaging and quantitative analysis of Cy7.5 fluorescent signal in aorta tissues. ApoE−/− mice fed with high fat food for 1 month were i.v. administered with Cy7.5, Cy7.5-NPs, MM-Cy7.5-NPs, and Cy7.5-NPs/MAs, respectively. n = 3 aorta tissues from different mice. Scale bar: 15 mm. d Schematic illustration of atherosclerotic mouse model development and treatment with various formulations (AT, AT-NPs, MM-AT-NPs, and AT-NPs/MAs). e ORO stained aorta tissues collected from atherosclerotic mice after treatment with various formulations (AT, AT-NPs, MM-AT-NPs, and AT-NPs/MAs) at equivalent dosage of 2 mg kg−1 AT per week. n = 10 aorta tissues from different mice. Scale bar: 5 mm. f Quantitative analysis of lesion area in aorta tissues (n = 10). All data were presented as mean ± s.d. Statistical analysis was conducted using one-way ANOVA. *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001. Source data are provided as a Source Data file.
