Table 1 Parameters varied in the clinical trial simulation.

From: Designing antifilarial drug trials using clinical trial simulators

Parameter

Values

Endemicity

40% or 50% microfilarial prevalence among individuals aged ≥5 years

Inclusion criteria

>0, >4 or >8 microfilariae /mg skin

Diagnostic protocol

2 or 4 skin snips per participant

Macrofilaricidal efficacya

60%, 75% or 90%

Pharmacodynamics (PD) profile

Macrofilaricidal-only macrofilaricide (MOM) or macrofilaricidal & microfilaricidalb macrofilaricide (MAMM)

  1. aMacrofilaricidal efficacy is defined as the probability (expressed as a percentage) that an adult Onchocerca volvulus worm is killed within three months of (single dose) treatment with the hypothetical drug.
  2. bMicrofilaricidal effect is assumed to be identical to that of ivermectin (excluding the temporary sterilisation or so-called embryostatic effect, see Supplementary Methods).
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