Fig. 3: Projections of area under the curve (AUC) characterizing predictive performance of PRS as sample size for GWAS increases. | Nature Communications

Fig. 3: Projections of area under the curve (AUC) characterizing predictive performance of PRS as sample size for GWAS increases.

From: Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Fig. 3: Projections of area under the curve (AUC) characterizing predictive performance of PRS as sample size for GWAS increases.

Results are shown for PRS including SNPs at the optimized p value threshold. The dotted horizontal red line indicates the maximum AUC achievable according to the estimate of GWAS heritability. Colored dots correspond to sample size for largest published GWAS and those for doubled and quadruped sizes. For oropharyngeal cancer, the projections at the “current sample size” are based on a sample size of 25K cases and 25K controls. For breast and esophageal cancer, the projections at the “current sample size” are based on the current largest GWAS sample sizes: 123K cases and 106K controls and 10K cases and 17K controls, respectively. For all other cancer sites, the projections at the “current sample size” are based on the GWAS sample sizes in Supplementary Table 1. CLL chronic lymphocytic leukemia.

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