Fig. 4: Projections of relative risks for individuals at or higher than 99th percentile of PRS as sample size for GWAS increases.

Results are shown where PRS is built based on SNPs at optimized p value threshold. The dotted horizontal red line indicates the maximum relative risk achievable according to estimate of GWAS heritability. Colored dots correspond to sample size for the largest published GWAS and those for doubled and quadruped sizes. y-Axis is presented in log10 scale. For oropharyngeal cancer, the projections at the “current sample size” are based on a sample size of 25K cases and 25K controls. For breast and esophageal cancer, the projections at the “current sample size” are based on the current largest GWAS sample sizes: 123K cases and 106K controls and 10K cases and 17K controls, respectively. For all other cancer sites, the projections at the “current sample size” are based on the GWAS sample sizes in Supplementary Table 1. CLL chronic lymphocytic leukemia.