Fig. 5: Projected distribution of average residual lifetime risk in the US population of non-Hispanic whites aged 30–75 years. | Nature Communications

Fig. 5: Projected distribution of average residual lifetime risk in the US population of non-Hispanic whites aged 30–75 years.

From: Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Fig. 5: Projected distribution of average residual lifetime risk in the US population of non-Hispanic whites aged 30–75 years.

The risk is obtained according to variation of polygenic risk scores. The projections are shown for PRS built based on GWAS with current, doubled and quadrupled sample sizes and the best PRS that corresponds to limits defined by heritability. The projections are obtained by combining information on projected population variance of PRS, age-specific population incidence rate, competing risk of mortality and current distribution of age according to US 2016 census. For oropharyngeal cancer, the projections at the “current sample size” are based on a sample size of 25K cases and 25K controls. For breast and esophageal cancer, the projections at the “current sample size” are based on the current largest GWAS sample sizes: 123K cases and 106K controls and 10K cases and 17K controls, respectively. For all other cancer sites, the projections at the “current sample size” are based on the GWAS sample sizes in Supplementary Table 1. CLL chronic lymphocytic leukemia.

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