Table 1 Blood and urine chemistries of male WT and Q140K+/+ mice.

From: The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

 

Blood chemistry

 

Urine chemistry

 

WT (n = 8a)

Q141K+/+ (n = 7a)

 

WT (n = 6)

Q141K+/+ (n = 6b)

Na+ [mmol/l]

144.125 ± 1.48

144.71 ± 0.95

Na+ [mmol/l]

39.60 ± 2.92

49.02 ± 3.85 [p = 0.048]

K+ [mmol/l]

4.60 ± 0.18

5.17 ± 0.19 [p = 0.027]

K+ [mmol/l]

90.67 ± 5.96

99.70 ± 4.81

Cl− [mmol/l]

114.88 ± 1.54

111.71 ± 0.91

Cl- [mmol/l]

90.77 ± 9.23

107.75 ± 8.21

BUN [mg/dl]

26.29 ± 0.78

24.57 ± 1.97

FENa+ [%]

0.47 ± 0.06

0.73 ± 0.1 [p = 0.024]

Hct [%PCV]

35.50 ± 0.88

38.14 ± 1.32

FEK+ [%]

33.5 ± 5.7

34.4 ± 3.2

pH

7.10 ± 0.03

7.18 ± 0.03

FECl− [%]

1.4 ± 0.25

1.8 ± 0.16

PCO2 [mmHg]

62.08 ± 4.45

55.61 ± 2.63

AnGap [mmol/l]

39.50 ± 4.89

40.97 ± 9.70

HCO3 [mmol/l]

19.44 ± 0.78

20.21 ± 0.68

UV [ml/24 h]

4.49 ± 0.69

3.94 ± 0.32

Beecf [mmol/l]

−11.50 ± 0.58

−8.83 ± 1.08 [p = 0.038]

Osmolarity [mmol/kg]

808.33 ± 61.03

973.67 ± 65.08 [p = 0.047]

AnGap [mmol/l]

17.33 ± 0.49

21.00 ± 1.67 [p = 0.02]

   

Hb [g/dl]

12.09 ± 0.30

12.97 ± 0.37

 

WT (n = 9)

Q141K+/+ (n = 11)

   

GFR

207.2 ± 30.0

150.9 ± 7.8 [p = 0.031]

  1. Blood, serum, and urine chemistries from WT and Q140K+/+ male animals. Blood chemistries acquired using the iSTAT device (see “Methods” section).
  2. Bold values are significant; statistical analysis: Student’s t-tests; ±SEM.
  3. BUN blood urea nitrogen, Hct hematocrit, Beecf base excess, AnGap anion gap, Hb hemoglobin, FE fractional excretion, UV urinary volume (rate), GFR estimated glomerular filtration rate.
  4. aGroup variability; WT: K+ n = 6; BUN n = 7; Beecf/AnGap n = 6; Q140K+/+: Beecf n = 6; AnGap n = 5.
  5. bGroup variability; Q140K+/+: FENa+ n = 4; FEK+/ FECl− n = 5.
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