Fig. 1: Schematic illustration of Cu5.4O ultrasmall nanoparticles in the treatment of ROS-related diseases.

Cu5.4O ultrasmall nanoparticles with multiple enzyme-mimicking and broad-spectrum ROS scavenging ability are synthesized by a simple and green method. Due to the robust ROS scavenging ability in vivo, Cu5.4O ultrasmall nanoparticles exhibit therapeutic effect against broad ROS-related diseases, including acute kidney injury, acute liver injury and diabetic wound healing.