Fig. 2: Enrichment of RBP features in our RNA fold interactome.
From: The RNA fold interactome of evolutionary conserved RNA structures in S. cerevisiae
a Isoelectric point density of the RNA fold interactome (orange), measured proteome (green) and the predicted proteome (blue) shows bias for RBPs. b Classification of RBP candidates based on GO-term analysis. Comparison of the measured proteome (background) and the RNA fold interactome. Enrichment of RNA binding and RNA-related GO terms was calculated with Fisher test odds ratio = 2.9, p-value = 6.2e−08. c Classification of the interactors based on their cellular localization. d Schematic of tRNA synthetases domain organization. tRNA synthetases identified in our screen are annotated in black. e Count of RBP candidates with RNA-related annotated Pfam protein domain (Fisher test odds ratio = 4.80, p-value < 2.2e−16). Shown are the measured proteome (background) and the RNA fold interactome. f 12 most abundant RBDs of our RNA fold interactome. g Distribution of predicted disordered regions for the RNA fold interactome (orange), measured proteome (green) and predicted proteome (blue) shows enrichment among RBPs. h Characterization of RNA fold interactome by GO annotations and protein domain-based classification.
