Fig. 3: Phenol-binding pocket and the coiled-coil B-linkers.
From: Tetrameric architecture of an active phenol-bound form of the AAA+ transcriptional regulator DmpR
a Positions of phenol and zinc inside the core (β/α)4 barrel scaffold of the sensory domain. b Key residues in the phenol-binding pocket and residues involved in zinc coordination are shown as sticks. c Depiction of the hydroxyl group of phenol interacting with His100 and Trp128 (left); sequence alignment of five aromatic compound-binding transcriptional activators (right). DmpR, P. putida KCTC 1452; PoxR, Ralstonia sp. E2; MopR, Acinetobacter guillouiae; and XylR, Pseudomonas putida. d The interface of the coiled-coil B-linkers with the strips of leucine residues highlighted within the enlarged box. e B-factor putty tube representation of the B-linker in the ATPase domain connection loop. Orange and red colours and a wider tube indicate regions with high B-factors, whereas shades of green and narrower tubes indicate regions with low B-factors. The putative ATP-binding site is shown in dot representation.
