Fig. 1: Structure of MavC in complex with conjugated UBE2N~Ub. | Nature Communications

Fig. 1: Structure of MavC in complex with conjugated UBE2N~Ub.

From: Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors

Fig. 1: Structure of MavC in complex with conjugated UBE2N~Ub.

a Domain organization of MavC and conjugated UBE2N~Ub. b, c Two views of cartoon (upper) and surface (lower) representations of the MavC+UBE2N~Ub complex, with the same color code as in a. The isopeptide bond between UBE2N-K92 and Ub-Q40 was highlighted in red circles. d Structural superimposition of MavC in apo (PDB: 5TSC) and UBE2N-bound states and conformational changes of the Insertion domain upon binding to UBE2N. e Detailed hydrogen bonding interactions between MavC catalytic residues and the K92–Q40 isopeptide.

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