Fig. 2: Biological pathways affected by mismatch to the phase of host rhythms. | Nature Communications

Fig. 2: Biological pathways affected by mismatch to the phase of host rhythms.

From: Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms

Fig. 2: Biological pathways affected by mismatch to the phase of host rhythms.

a Time series gene expression view of genes that displayed with 24 h rhythmicity in matched parasites but lost rhythmicity in mismatched parasites. Genes were sorted based on phase of maximum expression and segregated into 12 groups with each group representing 2 h phase clusters. Line plots along the sides of the heat map represent expression profiles of individual genes significantly enriched to gene ontology terms (FDR corrected p < 0.05, hypergeometric test, one-sided) representing few crucial biological processes. The Y axis represents relative expression of genes at each time point determined by count level expression of each gene normalized by its mean across 11 time points. b Heatmaps illustrating the expression patterns of 24 h rhythmic genes for matched and mismatched parasites that are involved in the ubiquitin and proteasome systems, and the DNA replication and glycolysis pathways. These genes lost rhythmicity in mismatched parasites. Genes have been sorted based on the phase of maximum expression. The color scheme represents the row Z-score. Each time point is represented by the expression heatmap of two biological replicates.

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