Fig. 6: OFC projection to V1 contributes to visual associative learning.
From: Orbitofrontal control of visual cortex gain promotes visual associative learning
a Schematic of the strategy for inactivating OFC projection to V1. b Effect of inactivating OFC projection to V1 during No–Go trials. n = 9 and 13 for EGFP- and Jaws-expressing mice, respectively. For discriminability: F(1,20) = 10.24, **P = 0.004. For hit rate: F(1,20) = 13.38, **P = 0.002. For CR rate: F(1,20) = 6.69, *P = 0.02. Two-way ANOVA with mixed design. c Effect of inactivating OFC projection to V1 during Go trials. n = 11 and 12 for EGFP- and Jaws-expressing mice, respectively. For discriminability: F(1,21) = 0.13, P = 0.72. For hit rate: F(1,21) = 0.24, P = 0.63. For CR rate: F(1,21) = 0.13, P = 0.72. Two-way ANOVA with mixed design. d Schematic of the strategy for activating SST interneurons in V1. e Effect of activating SST interneurons in V1 during No–Go trials. n = 10 and 11 for tdTomato- and ChrimsonR-expressing mice, respectively. Sessions 1–9, with laser stimulation; sessions 10–13, without laser stimulation. For discriminability in sessions 1–9: F(1,19) = 10.44, **P = 0.004; discriminability in sessions 10–13: F(1,19) = 11.93, **P = 0.003. For hit rate in sessions 1–9: F(1,19) = 4.37, P = 0.05; hit rate in sessions 10–13: F(1,19) = 6.07, *P = 0.02. For CR rate in sessions 1–9: F(1,19) = 10.63, **P = 0.004; CR rate in sessions 10–13: F(1,19) = 9.84, **P = 0.005. Two-way ANOVA with mixed design. For b, c, e, source data are provided as a Source Data file. Error bars, mean ± s.e.m.
