Fig. 6: Inhibition of MSPV-LCA3 projection impairs the retrieval of SWM.
From: The lateralization of left hippocampal CA3 during the retrieval of spatial working memory
a Schematic of AAV-retro retrograde optogenetic system in PV-Cre mice. b Confocal images of coronal sections showing that mCherry+ cells were co-labeled with PV (white) neurons. Scale bar: left is 200 μm, right is 50 μm. c Percentage of correct performance in mice receiving inhibition of MSPV-LCA3 (n = 7) or MSPV-RCA3 (n = 5) during the choice phase (two-tailed paired t-test, LCA3: **P = 0.0019, RCA3: P > 0.9999). d Schematic of AAV-retro retrograde optogenetic system in Chat-Cre mice. e Confocal images of coronal sections showing that mCherry+ cells were co-labeled with cholinergic (white) neurons. Scale bar: left is 200 μm, right is 50 μm. f Percentage of correct performance in mice receiving inhibition of MSChat-LCA3 (n = 6) or MSChat-RCA3 (n = 6) during the choice phase (two-tailed paired t-test, LCA3: P = 0.2031, RCA3: P = 0.7412). g A proposed model for MSPV-LCA3 projection that modulates the lateralization of SWM. Source data are provided as a Source Data file.
