Fig. 3: Substrate scope of aryl methyl sulfoxides with 2ga. | Nature Communications

Fig. 3: Substrate scope of aryl methyl sulfoxides with 2ga.

From: Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond

Fig. 3

aUnless noted, all reactions were conducted with 1 (0.2 mmol), 2 g (0.4 mmol), KOtBu (0.4 mmol) in DME (0.4 mL) under argon atmosphere at 110 °C for 12 h. b2g (3.0 equiv), KOtBu (3.0 equiv) at 110 °C for 24 h. c2g (3.0 equiv), KOtBu (3.0 equiv). d40 °C; e2g (3.0 equiv), KOtBu (4.0 equiv) at 100 °C for 30 h. fLarge scale reaction: 1q (5.5 mmol), 2g (11.0 mmol), KOtBu (11.0 mmol) in DME (11.0 mL) under argon atmosphere at 110 °C for 12 h. g1u (4.0 equiv), 2g (1.0 equiv), KOtBu (2.0 equiv) at 40 °C for 48 h.

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