Fig. 4: Gram-sale synthesis and functionalisation and demonstration of utility. | Nature Communications

Fig. 4: Gram-sale synthesis and functionalisation and demonstration of utility.

From: Stereospecific Si-C coupling and remote control of axial chirality by enantioselective palladium-catalyzed hydrosilylation of maleimides

Fig. 4

a Gram-scale reaction. Compared with the small-scale reaction, using substrates 1a and 2a in a gram-scale reaction produced the desired product 3a with the same level of enantiomeric excess (ee) and yield. b The silyl succinimides can be readily reduced to the stable silylpyrrolidine that could be transferred into structurally diverse and chiral N-heterocycles without racemisation. DMAD dimethyl acetylenedicarboxylate, PFNB petafluoronitrobenzene, CFL compact fluorescent light, ct the value of chirality transfer.

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