Fig. 6: Interactions of TCRs with the p53R175H peptide.
From: Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen
a Interactions between 12-6 (left), 38-10 (center), and 1a2 (right) and the p53R175H peptide. The side chains of contacting residues are shown in stick representation with carbon atoms in green (TCR α chain), violet (TCR β chain), orange (p53R175H), or cyan (mutated P8 His), nitrogen atoms in dark blue, oxygen atoms in red, and sulfur atoms in yellow. Peptide residues are identified by one-letter amino acid designation followed by position (p) number. Hydrogen bonds are indicated by red dashed lines. b Comparison of interactions between 12-6 (left), 38-10 (center), and 1a2 (right) and the p53R175H peptide. Hydrogen bonds are red dotted lines and van der Waals contacts are black dotted lines. For clarity, not all van der Waals contacts are shown. c Close-up of interactions between 12-6 (left), 38-10 (center), and 1a2 (right) and P8 His.
