Fig. 1: Mice lacking Gi signaling in adipocytes show metabolic impairments when maintained on a HFD. | Nature Communications

Fig. 1: Mice lacking Gi signaling in adipocytes show metabolic impairments when maintained on a HFD.

From: Adipocyte Gi signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity

Fig. 1

a Body weight growth curves of control and adipo-Gi KO mice (males) maintained on a HFD. b Fat and lean body mass of control and adipo-Gi KO mice maintained on HFD for 8 weeks. c Weight of inguinal white adipose tissue (iWAT), epididymal white adipose tissue (eWAT), brown adipose tissue (BAT), and liver of control and adipo-Gi KO mice fed with HFD for 8 weeks. d–f Freely fed and fasting blood glucose (d), plasma insulin (e), and plasma free fatty acid (FFA) levels (f) of control and adipo-Gi KO mice maintained on HFD for 8 weeks. g–i In vivo metabolic tests carried out with control and adipo-Gi KO mice maintained on HFD for 8 weeks. g I.p. glucose tolerance test (1 g/kg glucose; IGTT). h Insulin tolerance test (1 U/kg insulin, i.p.; ITT). i Pyruvate tolerance test (2 g/kg pyruvate, i.p.; PTT). Data are given as means ± s.e.m. P values are indicated in the different panels (a, g–i: two-way ANOVA followed by Bonferroni’s post hoc test; b–f: two-tailed Student’s t test). Source data are provided as a Source data file.

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