Fig. 10: Chronic activation of adipocyte Gi signaling improves glucose homeostasis. | Nature Communications

Fig. 10: Chronic activation of adipocyte Gi signaling improves glucose homeostasis.

From: Adipocyte Gi signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity

Fig. 10

a Scheme of the experimental design used (top). Control and adipo-GiD mice (males) consumed a HFD for 6 weeks. During the last 12 days, mice received daily i.p. injections of CNO (10 mg/kg). b Plasma free fatty acid (FFA) levels during chronic CNO treatment of HFD adipo-GiD mice and control littermates. Plasma FFA levels were determined daily before and 30 min after CNO treatment. c Insulin tolerance test (ITT) after chronic CNO treatment for 8 days (0.75 U/kg insulin, i.p.). d I.p. glucose tolerance test (IGTT) after chronic CNO treatment for 10 days (1 g/kg glucose). e Plasma leptin levels of HFD adipo-GiD and control mice after CNO treatment for 12 days (control, n = 6; adipo-GiD, n = 8). f Liver triglyceride content of HFD adipo-GiD and control mice after CNO treatment for 12 days (control, n = 6; adipo-GiD, n = 7). Data are given as means ± s.e.m. P values are indicated in the different panels (b–d: two-way ANOVA followed by Bonferroni’s post hoc test; f: two-tailed Student’s t test). Source data are provided as a Source data file.

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