Fig. 4: Co-registration of microscopic and mesoscopic vascular responses to odor.
From: Transfer functions linking neural calcium to single voxel functional ultrasound signal
a Microscopic responses were acquired in a glomerulus located in the center of a fUS voxel. The four panels illustrate Ca2+, RBC velocity, and the three types of fUS responses (from the specific co-registered single voxel and the group of six voxels) to four odor stimulation protocols (120 ms and 5 s stimulations at two concentrations). All responses increased with time and odor concentration. The ΔPD/PD fUS traces from single voxels are in bold. b Comparison of the μTF and the mesoscopic TF (MTF) optimized between ΔCa2+ (ET 1%, 5 s) and the co-registered single fUS voxel signal. c Prediction quality (Pearson coefficients) of single and six voxels fUS responses using either the μTF (red), the neuron-derived MTF (orange) (n = 5 mice). Note that in one mouse (bottom left plot), the single voxel signal ∼0 (open circles). Source data are provided as a Source Data file.
